Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name tin
Flybase description The gene tinman is referred to in FlyBase by the symbol Dmel\tin (CG7895, FBgn0004110).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -35.5646 -19.3331 -33.652662 -30.391 -44.580904 -37.8819 -41.26198 -32.692795
    Affimetrix absolute value 3.275 3.367 3.191 3.466 3.296 3.319 3.186 3.251
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: cardioblast differentiation; gonadal mesoderm development; germ cell migration; embryonic heart tube development; pericardial cell differentiation; cardiac cell differentiation; lymph gland development; salivary gland morphogenesis; mesoderm development; cardiac muscle cell differentiation.
58 alleles are reported.
The phenotypes of these alleles are annotated with 43 unique terms, many of which group under: organ system; primordium; organ system subdivision; late extended germ band embryo; hypodermal muscle of larval abdomen; A1-7 transverse muscle; midgut constriction; embryonic/larval dorsal vessel; non-connected developing system; nervous system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression.
Peak expression observed within 00-06 hour embryonic stages.