Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name 18w
Flybase description The gene 18 wheeler is referred to in FlyBase by the symbol Dmel\18w (CG8896, FBgn0004364).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -12.7478 -0.3667 -10.694544 -14.0868 -17.340699 -4.6737 -3.11913 -8.675498
    Affimetrix absolute value 4.762 7.576 4.774 4.599 4.681 6.361 6.93 5.212
    Affymetric present call in "x" number of chips 3 3 3 2 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: transmembrane receptor activity.
There is experimental evidence that it is involved in the biological process: immune response; cell adhesion; anatomical structure morphogenesis; antibacterial humoral response.
20 alleles are reported.
The phenotypes of these alleles are annotated with: leg; antenna; haltere; mesothoracic tergum; wing.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Cysteine-rich flanking region, C-terminal domain; Interleukin-1 receptor, type I/Toll precursor; Leucine-rich repeat; Leucine-rich repeat, typical subtype; Leucine-rich repeat-containing N-terminal; Toll-Interleukin receptor.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages.