Flygut: an atlas of the Drosophila adult midgut

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Gene name Gap1
Flybase description The gene GTPase-activating protein 1 is referred to in FlyBase by the symbol Dmel\Gap1 (CG6721, FBgn0004390).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.1519 -1.6107 -2.337272 -2.2014 -3.550422 -2.8988 -3.77258 -2.920417
    Affimetrix absolute value 6.762 6.947 6.969 7.298 6.948 7.045 6.662 6.723
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: Ras GTPase activator activity.
There is experimental evidence that it is involved in the biological process: Ras protein signal transduction; female meiosis chromosome segregation; positive regulation of R7 cell differentiation; tracheal outgrowth, open tracheal system; mitosis; imaginal disc-derived wing morphogenesis; sister chromatid cohesion; neurogenesis.
61 alleles are reported.
The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: organ system subdivision; external compound sense organ; adult segment; peripheral nervous system; adult mesothoracic segment; adult cuticle; nervous system; nuclear part; blastoderm embryo; rhabdomere; egg; heart primordium; gastrula embryo.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; Pleckstrin homology domain; Pleckstrin homology-type; Ras GTPase-activating protein; Ras GTPase-activating protein, conserved site; Rho GTPase activation protein; Zinc finger, Btk motif.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed at stages throughout embryogenesis, in adult female stages.
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