Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name 5-HT7
Flybase description The gene Serotonin receptor 7 is referred to in FlyBase by the symbol Dmel\5-HT7 (CG12073, FBgn0004573).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -45.9244 -32.6818 -48.326921 -44.7298 -73.828283 -56.0639 -62.67925 -52.557157
    Affimetrix absolute value 2.898 2.622 2.585 2.905 2.568 2.768 2.595 2.553
    Affymetric present call in "x" number of chips 0 0 1 1 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: G-protein coupled amine receptor activity; serotonin receptor activity.
There is experimental evidence that it is involved in the biological process: male courtship behavior, proboscis-mediated licking; female mating behavior; male mating behavior; courtship behavior; male courtship behavior, orientation prior to leg tapping and wing vibration; male courtship behavior, veined wing vibration.
10 alleles are reported.
The phenotype of these alleles is annotated with: Malpighian tubule.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Dopamine receptor; GPCR, rhodopsin-like superfamily; GPCR, rhodopsin-like, 7TM.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 18-24 hour embryonic stages, during early larval stages.