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|Flybase description||The gene Roughened is referred to in FlyBase by the symbol Dmel\R (CG1956, FBgn0004636).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: GTPase activity.
There is experimental evidence that it is involved in the biological process: regulation of cell shape; regulation of embryonic cell shape; germ-line stem cell maintenance; dorsal closure; hemocyte migration; cell adhesion; substrate-dependent cell migration, cell extension.
43 alleles are reported.
The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: external compound sense organ; organ system subdivision; peripheral nervous system; female germline cyst; nervous system; organ system; germarium; embryonic/larval hemocoel; hemocyte; cuticle.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Ras type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 00-12 hour embryonic stages.