Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name drk
Flybase description The gene downstream of receptor kinase is referred to in FlyBase by the symbol Dmel\drk (CG6033, FBgn0004638).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.8604 -2.2458 -5.806384 -3.106 -7.931181 -3.2961 -2.04264 -5.847943
    Affimetrix absolute value 7.537 6.456 5.648 6.77 5.801 6.841 7.538 5.764
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; SH3/SH2 adaptor activity; sevenless binding.
There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; anatomical structure development; associative learning; learning or memory; learning; regulation of developmental process; cellular component organization or biogenesis; memory; embryonic development via the syncytial blastoderm; organ morphogenesis.
37 alleles are reported.
The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: organ system subdivision; larval abdominal segment; abdominal lateral pentascolopidial chordotonal organ lch5; larval abdominal segment 5; adult segment; abdominal segment 7; abdominal 2 ventral monoscolopidial chordotonal organ vch1; imaginal precursor; external compound sense organ; abdominal 7 ventral monoscolopidial chordotonal organ vch1.
It has 6 annotated transcripts and 6 annotated polypeptides.
Protein features are: Neutrophil cytosol factor 2 p67phox; SH2 motif; Src homology-3 domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during early pupal stages.