Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name hh
Flybase description The gene hedgehog is referred to in FlyBase by the symbol Dmel\hh (CG4637, FBgn0004644).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.7087 -6.5418 -3.469002 -2.502 -1.99826 -1.6941 -7.19824 -2.422024
    Affimetrix absolute value 6.192 4.984 6.383 7.077 7.777 7.87 5.807 6.977
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: cell surface binding; protein binding.
There is experimental evidence for 25 unique biological process terms, many of which group under: anatomical structure development; biological regulation; localization; organ morphogenesis; sensory organ development; cellular component organization or biogenesis; cellular process involved in reproduction; multicellular organismal reproductive process; organ development; locomotion.
177 alleles are reported.
The phenotypes of these alleles are annotated with 190 unique terms, many of which group under: organ system subdivision; adult segment; primordium; late extended germ band embryo; adult mesothoracic segment; ventral nerve cord primordium; organ system; abdominal ventral denticle belt; imaginal precursor; germarium.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Hedgehog, N-terminal signaling domain; Hedgehog/DD-peptidase; Hedgehog/intein hint domain, C-terminal; Hedgehog/intein hint, N-terminal; Intein splice site; Peptidase C46, hedgehog protein; Peptidase C46, hedgehog protein, hint region.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.