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|Flybase description||The gene Topoisomerase 1 is referred to in FlyBase by the symbol Dmel\Top1 (CG6146, FBgn0004924).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: DNA topoisomerase activity; DNA topoisomerase type I activity; protein kinase activity.
There is experimental evidence that it is involved in the biological process: instar larval development; cell proliferation; chromosome segregation; protein phosphorylation; DNA topological change; multicellular organismal development; oogenesis; embryo development; chromosome condensation.
36 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; multicellular structure; female germline cyst; organ system subdivision; germarium; nucleus; egg; sensillum; cell cycle; imaginal precursor; adult segment.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: DNA breaking-rejoining enzyme, catalytic core; DNA topoisomerase I, C-terminal; DNA topoisomerase I, C-terminal, eukaryotic-type; DNA topoisomerase I, DNA binding, eukaryotic-type; DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type; DNA topoisomerase I, active site; DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type; DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type; DNA topoisomerase I, catalytic core, eukaryotic-type; DNA topoisomerase I, domain 1; DNA topoisomerases I, dispensable insert, eukaryotic-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.