Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name ewg
Flybase description The gene erect wing is referred to in FlyBase by the symbol Dmel\ewg (CG3114, FBgn0005427).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -17.662 -8.7513 -12.722551 -13.5106 -19.322273 -16.3206 -20.10617 -14.687383
    Affimetrix absolute value 4.266 4.5 4.511 4.659 4.489 4.542 4.24 4.399
    Affymetric present call in "x" number of chips 2 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; DNA binding.
There is experimental evidence that it is involved in the biological process: negative regulation of synaptic growth at neuromuscular junction; central nervous system development; imaginal disc morphogenesis; muscle organ development.
77 alleles are reported.
The phenotypes of these alleles are annotated with: dorsal medial muscle; NMJ bouton; embryonic/larval neuromuscular junction; mesothoracic tergum; wing; lateral oblique dorsal muscle.
It has 10 annotated transcripts and 10 annotated polypeptides.
Protein features are: Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain; Nuclear respiratory factor-1, activation binding domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 06-18 hour embryonic stages.