Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name lbl
Flybase description The gene ladybird late is referred to in FlyBase by the symbol Dmel\lbl (CG6570, FBgn0008651).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -55.5761 -38.6868 -48.445676 -59.3264 -71.528817 -57.8963 -61.8668 -55.68013
    Affimetrix absolute value 2.613 2.356 2.592 2.497 2.605 2.712 2.604 2.461
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 1 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: leg morphogenesis; myoblast fusion; genital disc morphogenesis; regulation of neuron differentiation; regulation of transcription, DNA-dependent; skeletal muscle tissue development; cell migration; epidermis development; regulation of cell fate specification; myoblast proliferation.
9 alleles are reported.
The phenotypes of these alleles are annotated with: prothoracic segmental nerve; central nervous system; intersegmental nerve; dorsal denticle; EL neuron.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Helix-turn-helix motif, lambda-like repressor; Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression.
Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages.