Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name brat
Flybase description The gene brain tumor is referred to in FlyBase by the symbol Dmel\brat (CG10719, FBgn0010300).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -48.3987 -15.8729 -23.357386 -34.5441 -42.888688 -33.6618 -48.80874 -37.243954
    Affimetrix absolute value 2.818 3.669 3.643 3.325 3.34 3.553 2.98 3.061
    Affymetric present call in "x" number of chips 0 3 3 1 1 3 1 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; translation repressor activity.
There is experimental evidence for 16 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular component organization or biogenesis; cell division; cellular macromolecule metabolic process; cell fate commitment; cell fate determination; ncRNA metabolic process; neuroblast fate commitment; multicellular organismal reproductive process; gene expression; multicellular organismal process.
105 alleles are reported.
The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: organ system; organ system subdivision; germarium; female germline cyst; multicellular structure; nervous system; somatic cell; embryonic abdomen; embryonic segment; imaginal precursor; external compound sense organ; adult segment.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: NHL repeat; NHL repeat, subgroup; Six-bladed beta-propeller, TolB-like; Zinc finger, B-box.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages.