Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Tbh
Flybase description The gene Tyramine β hydroxylase is referred to in FlyBase by the symbol Dmel\Tbh (CG1543, FBgn0010329).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -33.4754 -24.7438 -37.023542 -43.7712 -58.928276 -45.4916 -49.88779 -38.230432
    Affimetrix absolute value 3.39 3.004 3.017 2.941 2.881 3.063 2.928 3.01
    Affymetric present call in "x" number of chips 0 2 1 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: dopamine beta-monooxygenase activity.
There is experimental evidence for 13 unique biological process terms, many of which group under: behavioral interaction between organisms; multicellular organismal process; biological regulation; multi-organism process; multicellular organismal reproductive process; locomotory behavior; mating; learning or memory; regulation of biological process; aggressive behavior.
14 alleles are reported.
The phenotype of these alleles is annotated with: larva.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Copper type II, ascorbate-dependent monooxygenase, N-terminal; Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site; Copper type II, ascorbate-dependent monooxygenase-like, C-terminal; DOMON domain; Dopamine-beta-monooxygenase; PHM/PNGase F-fold domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected.
Peak expression observed within 18-24 hour embryonic stages, during early larval stages.