Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name htl
Flybase description The gene heartless is referred to in FlyBase by the symbol Dmel\htl (CG7223, FBgn0010389).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 0.4129 -3.7902 -10.253382 -5.2841 -15.113077 -8.4166 -5.11922 -7.12115
    Affimetrix absolute value 8.5 5.758 4.819 6.004 4.856 5.497 6.236 5.478
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity; fibroblast growth factor receptor activity.
There is experimental evidence for 20 unique biological process terms, many of which group under: anatomical structure development; organ development; mesoderm morphogenesis; localization; muscle organ development; locomotion; cell fate commitment; cell fate determination; central nervous system development; gonadal mesoderm development; biological regulation; cellular process involved in reproduction.
38 alleles are reported.
The phenotypes of these alleles are annotated with 42 unique terms, many of which group under: organ system; primordium; hypodermal muscle of larval abdomen; late extended germ band embryo; organ system subdivision; germ layer; adult segment; non-connected developing system; nervous system; portion of tissue.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Tyrosine-protein kinase, fibroblast growth factor receptor; Tyrosine-protein kinase, fibroblast growth factor receptor-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages.