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|Flybase description||The gene heartless is referred to in FlyBase by the symbol Dmel\htl (CG7223, FBgn0010389).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity; fibroblast growth factor receptor activity.
There is experimental evidence for 20 unique biological process terms, many of which group under: anatomical structure development; organ development; mesoderm morphogenesis; localization; muscle organ development; locomotion; cell fate commitment; cell fate determination; central nervous system development; gonadal mesoderm development; biological regulation; cellular process involved in reproduction.
38 alleles are reported.
The phenotypes of these alleles are annotated with 42 unique terms, many of which group under: organ system; primordium; hypodermal muscle of larval abdomen; late extended germ band embryo; organ system subdivision; germ layer; adult segment; non-connected developing system; nervous system; portion of tissue.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Tyrosine-protein kinase, fibroblast growth factor receptor; Tyrosine-protein kinase, fibroblast growth factor receptor-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages.