Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name TfIIS
Flybase description The gene RNA polymerase II elongation factor is referred to in FlyBase by the symbol Dmel\TfIIS (CG3710, FBgn0010422).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.3919 -2.4837 -3.147719 -4.1436 -4.647014 -4.7526 -4.46106 -3.927136
    Affimetrix absolute value 6.647 6.307 6.526 6.346 6.568 6.336 6.413 6.289
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: translation elongation factor activity; DNA binding; zinc ion binding.
Based on sequence similarity, it is predicted to be involved in the biological process: regulation of transcription, DNA-dependent.
8 alleles are reported.
The phenotype of these alleles is annotated with: wing.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Transcription elongation factor S-II, central domain; Transcription elongation factor S-IIM; Transcription elongation factor, IIS; Transcription elongation factor, TFIIS; Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type; Transcription factor IIS, N-terminal; Zinc finger, TFIIS-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages.