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|Flybase description||The gene lethal (3) 02640 is referred to in FlyBase by the symbol Dmel\l(3)02640 (CG9165, FBgn0010786).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: hydroxymethylbilane synthase activity.
An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: peptidyl-pyrromethane cofactor linkage; tetrapyrrole biosynthetic process.
19 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Porphobilinogen deaminase, C-terminal domain; Porphobilinogen deaminase, N-terminal; Porphobilinogen deaminase, dipyrromethane cofactor binding site; Tetrapyrrole biosynthesis, hydroxymethylbilane synthase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.