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|Flybase description||The gene Grunge is referred to in FlyBase by the symbol Dmel\Gug (CG6964, FBgn0010825).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: histone deacetylase activity; repressing transcription factor binding; transcription corepressor activity; DNA binding.
There is experimental evidence that it is involved in the biological process: eye development; segment specification; negative regulation of epidermal growth factor receptor signaling pathway; embryonic pattern specification; segmentation; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived leg morphogenesis; negative regulation of transcription, DNA-dependent.
43 alleles are reported.
The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system subdivision; adult segment; external compound sense organ; organ system; cytoplasmic part; adult mesothoracic segment; thoracic segment; nervous system; compound cell cluster organ; organelle.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: Atrophin-like; ELM2 domain; Homeodomain-like; SANT domain, DNA binding; SANT, eukarya.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages.