Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Gug
Flybase description The gene Grunge is referred to in FlyBase by the symbol Dmel\Gug (CG6964, FBgn0010825).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.3042 -1.7978 -2.425702 -2.2534 -3.190465 -1.9986 -2.4669 -3.120034
    Affimetrix absolute value 7.221 6.776 6.912 7.244 7.09 7.565 7.269 6.616
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: histone deacetylase activity; repressing transcription factor binding; transcription corepressor activity; DNA binding.
There is experimental evidence that it is involved in the biological process: eye development; segment specification; negative regulation of epidermal growth factor receptor signaling pathway; embryonic pattern specification; segmentation; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived leg morphogenesis; negative regulation of transcription, DNA-dependent.
43 alleles are reported.
The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system subdivision; adult segment; external compound sense organ; organ system; cytoplasmic part; adult mesothoracic segment; thoracic segment; nervous system; compound cell cluster organ; organelle.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: Atrophin-like; ELM2 domain; Homeodomain-like; SANT domain, DNA binding; SANT, eukarya.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages.