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|Flybase description||The gene misshapen is referred to in FlyBase by the symbol Dmel\msn (CG16973, FBgn0010909).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity; MAP kinase kinase kinase kinase activity.
There is experimental evidence that it is involved in the biological process: regulation of cell shape; regulation of embryonic cell shape; dorsal closure; axon guidance; optic lobe placode development; JNK cascade; imaginal disc fusion, thorax closure; photoreceptor cell morphogenesis; nuclear migration.
42 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system subdivision; multi-cell-component structure; external compound sense organ; adult segment; peripheral nervous system; nervous system; cell projection; imaginal precursor; rhabdomere; synaptic neuropil subdomain; wing hair; primordium; axon.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Citron-like; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period.