Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name msn
Flybase description The gene misshapen is referred to in FlyBase by the symbol Dmel\msn (CG16973, FBgn0010909).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.8761 -1.2539 -2.208269 -2.2298 -3.399763 -3.2358 -3.16502 -2.852299
    Affimetrix absolute value 6.46 7.31 7.055 7.267 7.035 6.881 6.932 6.784
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity; MAP kinase kinase kinase kinase activity.
There is experimental evidence that it is involved in the biological process: regulation of cell shape; regulation of embryonic cell shape; dorsal closure; axon guidance; optic lobe placode development; JNK cascade; imaginal disc fusion, thorax closure; photoreceptor cell morphogenesis; nuclear migration.
42 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system subdivision; multi-cell-component structure; external compound sense organ; adult segment; peripheral nervous system; nervous system; cell projection; imaginal precursor; rhabdomere; synaptic neuropil subdomain; wing hair; primordium; axon.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Citron-like; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period.