Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name heph
Flybase description The gene hephaestus is referred to in FlyBase by the symbol Dmel\heph (CG31000, FBgn0011224).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -7.8864 -5.8037 -17.129418 -8.2233 -33.766776 -14.1317 -9.94415 -19.801574
    Affimetrix absolute value 5.436 5.116 4.105 5.391 3.706 4.753 5.269 4.023
    Affymetric present call in "x" number of chips 3 3 1 3 0 3 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: mRNA 3'-UTR binding; translation repressor activity, nucleic acid binding.
There is experimental evidence that it is involved in the biological process: spermatid development; imaginal disc-derived wing margin morphogenesis; sperm individualization; oocyte microtubule cytoskeleton polarization; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway; negative regulation of oskar mRNA translation.
113 alleles are reported.
The phenotypes of these alleles are annotated with: trichogen cell; elongation stage spermatid; macrochaeta; testis; mesothoracic tergum; wing; spermatid cyst; individualization stage spermatid; spermatozoon.
It has 24 annotated transcripts and 24 annotated polypeptides.
Protein features are: HnRNP-L/PTB/hephaestus splicing factor; Nucleotide-binding, alpha-beta plait; RNA recognition motif domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages, during early pupal stages.