Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Iswi
Flybase description The gene Imitation SWI is referred to in FlyBase by the symbol Dmel\Iswi (CG8625, FBgn0011604).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -8.9911 -3.0306 -7.251718 -4.105 -12.116233 -4.9583 -5.61327 -9.188302
    Affimetrix absolute value 5.245 6.02 5.36 6.382 5.198 6.256 6.067 5.137
    Affymetric present call in "x" number of chips 1 3 2 3 2 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; nucleosome-dependent ATPase activity; DNA-dependent ATPase activity.
There is experimental evidence for 13 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; chromatin organization; organelle organization; anatomical structure development; cellular macromolecular complex subunit organization; regulation of cellular macromolecule biosynthetic process; regulation of biological process; gene expression; chromosome organization.
18 alleles are reported.
The phenotypes of these alleles are annotated with: eye; wing disc; mechanosensory chaeta; polytene chromosome; dorsocentral bristle; euchromatin; mesothoracic tergum; condensed chromosome.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: ATPase, nucleosome remodelling ISWI, HAND domain; DEAD-like helicase; Helicase, C-terminal; Homeodomain-like; SANT domain, DNA binding; SANT, eukarya; SLIDE; SNF2-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages.