Flygut: an atlas of the Drosophila adult midgut

Mouche Logo lab lemaitre Bbcf logo

Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Mad
Flybase description The gene Mothers against dpp is referred to in FlyBase by the symbol Dmel\Mad (CG12399, FBgn0011648).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.3709 1.5158 -1.190191 -1.6876 -1.553122 -1.8642 -4.01278 -1.415268
    Affimetrix absolute value 6.664 8.177 7.926 7.652 8.136 7.667 6.57 7.766
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; sequence-specific DNA binding.
There is experimental evidence for 16 unique biological process terms, many of which group under: anatomical structure development; biological regulation; regulation of developmental process; post-embryonic organ morphogenesis; post-embryonic appendage morphogenesis; cellular process involved in reproduction; organ morphogenesis; multicellular organismal reproductive process; trunk segmentation; regulation of cellular macromolecule biosynthetic process; regulation of S phase of mitotic cell cycle; sensory organ development; regulation of multicellular organismal development.
83 alleles are reported.
The phenotypes of these alleles are annotated with 40 unique terms, many of which group under: organ system; adult segment; organ system subdivision; adult mesothoracic segment; nervous system; embryonic/larval tracheal system; germarium; synapse; somatic cell; imaginal precursor.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Dwarfin; MAD homology 1, Dwarfin-type; MAD homology, MH1; SMAD domain, Dwarfin-type; SMAD domain-like; SMAD/FHA domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis.