Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name insc
Flybase description The gene inscuteable is referred to in FlyBase by the symbol Dmel\insc (CG11312, FBgn0011674).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -7.0411 -3.2421 -1.925805 -3.4507 -2.875696 -2.3556 -22.46886 -2.633185
    Affimetrix absolute value 5.601 5.977 7.242 6.621 7.235 7.346 4.208 6.859
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: cytoskeletal adaptor activity; protein binding.
There is experimental evidence that it is involved in the biological process: RNA localization; protein localization; somatic muscle development; regulation of nervous system development; establishment of mitotic spindle localization; asymmetric neuroblast division; apical protein localization; regulation of asymmetric cell division; peripheral nervous system development.
72 alleles are reported.
The phenotypes of these alleles are annotated with 178 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; A1-7 oblique muscle; A1-7 transverse muscle; larval abdominal segment 5; organ system subdivision; hypodermal muscle of metathorax; adult abdominal myoblast; abdominal segment 7; A1-7 ventral oblique muscle 1.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Armadillo-like helical; Armadillo-type fold; Metal-dependent hydrolase HDOD.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 06-18 hour embryonic stages.