Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Dp
Flybase description The gene DP transcription factor is referred to in FlyBase by the symbol Dmel\Dp (CG4654, FBgn0011763).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.2975 -1.8934 -3.19824 -2.8658 -5.09236 -3.9035 -4.05601 -4.523021
    Affimetrix absolute value 6.021 6.718 6.571 6.873 6.442 6.597 6.539 6.209
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; DNA binding.
There is experimental evidence that it is involved in the biological process: positive regulation of gene expression; positive regulation of nurse cell apoptosis; oogenesis; dorsal/ventral axis specification, ovarian follicular epithelium; regulation of cell cycle; cell cycle; DNA damage response, signal transduction resulting in induction of apoptosis.
38 alleles are reported.
The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system subdivision; organ system; external compound sense organ; adult segment; female germline cyst; sensillum; nervous system; eo support cell; nucleus; egg; cell cycle; imaginal precursor.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Transcription factor DP; Transcription factor DP, C-terminal; Transcription factor DP, subgroup; Transcription factor E2F/dimerisation partner (TDP); Winged helix-turn-helix transcription repressor DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages, in adult female stages.