Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name CalpA
Flybase description The gene Calpain-A is referred to in FlyBase by the symbol Dmel\CalpA (CG7563, FBgn0012051).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.0549 -15.7663 -30.540077 -20.6439 -44.35274 -36.0072 -12.12767 -30.002326
    Affimetrix absolute value 6.095 3.705 3.287 4.023 3.311 3.392 4.993 3.365
    Affymetric present call in "x" number of chips 3 2 1 3 1 2 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: calcium-dependent cysteine-type endopeptidase activity.
There is experimental evidence that it is involved in the biological process: dorsal/ventral pattern formation; BMP signaling pathway involved in spinal cord dorsal/ventral patterning; cuticle development; phagocytosis, engulfment.
9 alleles are reported.
No phenotypic data is available.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Calcium-binding EF-hand; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand-like domain; Peptidase C2, calpain family; Peptidase C2, calpain, catalytic domain; Peptidase C2, calpain, domain III; Peptidase C2, calpain, large subunit, domain III; Peptidase, cysteine peptidase active site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 18-24 hour embryonic stages.