Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name alien
Flybase description The gene alien is referred to in FlyBase by the symbol Dmel\alien (CG9556, FBgn0013746).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.2433 1.2412 -0.363007 0.3346 -1.482915 -1.1807 -0.79537 -1.252354
    Affimetrix absolute value 8.106 7.924 8.135 8.391 8.216 8.322 8.047 7.944
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; nuclear hormone receptor binding; ligand-dependent nuclear receptor binding; protein homodimerization activity; transcription corepressor activity.
There is experimental evidence that it is involved in the biological process: protein stabilization; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of transcription, DNA-dependent; neurogenesis; phagocytosis, engulfment.
3 alleles are reported.
The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: PCI/PINT associated module; Proteasome component (PCI) domain; Tetratricopeptide-like helical; Winged helix-turn-helix transcription repressor DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages.