Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name imd
Flybase description The gene immune deficiency is referred to in FlyBase by the symbol Dmel\imd (CG5576, FBgn0013983).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.568 -3.6033 -5.467604 -6.9708 -9.239883 -8.4106 -9.43689 -7.415188
    Affimetrix absolute value 5.948 5.77 5.73 5.587 5.556 5.498 5.326 5.38
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: death domain binding; protein binding.
There is experimental evidence that it is involved in the biological process: immune response; response to bacterium; humoral immune response; positive regulation of innate immune response; nervous system development; positive regulation of antibacterial peptide biosynthetic process; antimicrobial humoral response; peptidoglycan recognition protein signaling pathway; antibacterial humoral response.
29 alleles are reported.
The phenotype of these alleles is annotated with: embryonic/larval fat body.
It has one annotated transcript and one annotated polypeptide.
Protein features are: DEATH-like; Death.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 06-12 hour embryonic stages, during late larval stages, during early pupal stages.