Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Hr38
Flybase description The gene Hormone receptor-like in 38 is referred to in FlyBase by the symbol Dmel\Hr38 (CG1864, FBgn0014859).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -26.5987 -14.6966 -18.613466 -24.9397 -34.484429 -28.201 -24.74655 -24.454577
    Affimetrix absolute value 3.689 3.751 3.968 3.749 3.676 3.755 3.951 3.645
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 1 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ligand-dependent nuclear receptor activity.
There is experimental evidence that it is involved in the biological process: cuticle development; phagocytosis, engulfment.
36 alleles are reported.
The phenotypes of these alleles are annotated with: leg; adult epidermis; adult cuticle; pupal epidermis; joint; pupal cuticle.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Nuclear hormone receptor, ligand-binding; Nuclear hormone receptor, ligand-binding, core; Retinoic acid receptor; Steroid hormone receptor; Zinc finger, NHR/GATA-type; Zinc finger, nuclear hormone receptor-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression.
Peak expression observed during early larval stages, during late pupal stages, in adult male stages.