Flygut: an atlas of the Drosophila adult midgut

Mouche Logo lab lemaitre Bbcf logo

Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name eIF-4E
Flybase description The gene Eukaryotic initiation factor 4E is referred to in FlyBase by the symbol Dmel\eIF-4E (CG4035, FBgn0015218).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 5.7127 6.8805 3.745041 4.4651 2.040155 3.3425 4.01565 3.17951
    Affimetrix absolute value 10.921 10.387 9.97 10.541 9.698 10.302 10.552 9.791
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: translation initiation factor activity; protein binding; eukaryotic initiation factor 4G binding; RNA cap binding; RNA 7-methylguanosine cap binding.
There is experimental evidence for 14 unique biological process terms, many of which group under: cellular component organization or biogenesis; cell cycle; cell cycle process; gene expression; programmed cell death; organelle organization; primary metabolic process; cellular macromolecule biosynthetic process; cellular biosynthetic process; gland morphogenesis; biological regulation; cell death.
40 alleles are reported.
The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; organ system subdivision; peripheral nervous system; external compound sense organ; thoracic segment; multicellular structure; cell cycle; synapse; epithelial furrow; adult segment.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: Eukaryotic translation initiation factor 4E (eIF-4E), conserved site; Translation Initiation factor eIF- 4e; Translation Initiation factor eIF- 4e-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression.
Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the pupal period, in adult female stages.