Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Iap2
Flybase description The gene Inhibitor of apoptosis 2 is referred to in FlyBase by the symbol Dmel\Iap2 (CG8293, FBgn0015247).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.35 1.6729 1.244662 -0.2803 -1.291121 -1.2408 -0.33747 -0.317312
    Affimetrix absolute value 8.835 8.353 8.486 8.449 8.401 8.264 8.534 8.253
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding.
There is experimental evidence that it is involved in the biological process: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; anti-apoptosis; negative regulation of caspase activity; sensory organ development; negative regulation of apoptosis; defense response to Gram-negative bacterium; peptidoglycan recognition protein signaling pathway; regulation of caspase activity; positive regulation of protein import into nucleus, translocation.
31 alleles are reported.
The phenotypes of these alleles are annotated with: wing disc; trichogen cell; mesothoracic tergum; pigment cell.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Baculoviral inhibition of apoptosis protein repeat; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.