Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name drl
Flybase description The gene derailed is referred to in FlyBase by the symbol Dmel\drl (CG17348, FBgn0015380).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.9186 -10.7002 -18.412502 -22.0373 -18.860936 -18.6603 -20.66256 -19.709787
    Affimetrix absolute value 6.131 4.206 3.975 3.951 4.531 4.347 4.187 4.011
    Affymetric present call in "x" number of chips 3 3 0 1 2 3 0 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: Wnt-protein binding.
There is experimental evidence that it is involved in the biological process: olfactory learning; axon guidance; learning or memory; memory; haltere development; signal transduction; muscle attachment; salivary gland morphogenesis; axon midline choice point recognition.
36 alleles are reported.
The phenotypes of these alleles are annotated with 56 unique terms, many of which group under: organ system subdivision; hypodermal muscle of larval abdomen; organ system; A1-7 transverse muscle; adult segment; non-connected developing system; abdominal 1 transverse muscle; cell body; abdominal 2 lateral transverse muscle 2; embryonic foregut.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; WIF domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed within 06-18 hour embryonic stages.