Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Apc
Flybase description The gene APC-like is referred to in FlyBase by the symbol Dmel\Apc (CG1451, FBgn0015589).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.8677 0.8548 -1.447648 -0.5774 -4.074621 -1.3524 -3.74939 -2.423975
    Affimetrix absolute value 6.135 8.163 7.687 8.103 6.834 8.147 6.693 7.121
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: beta-catenin binding.
There is experimental evidence for 13 unique biological process terms, many of which group under: system development; biological regulation; multicellular organismal development; cellular component organization or biogenesis; cellular process; regulation of Wnt receptor signaling pathway; cell proliferation; larval chitin-based cuticle development; localization; embryonic development via the syncytial blastoderm.
14 alleles are reported.
The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: external compound sense organ; organ system subdivision; peripheral nervous system; organ system; histaminergic neuron; adult; multi-tissue structure; male organism; region of integument; somatic cell of testis.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Adenomatous polyposis coli protein, 15 residue repeat; Adenomatous polyposis coli protein, cysteine-rich repeat; Armadillo; Armadillo-like helical; Armadillo-type fold.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the pupal period.