Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Cdk8
Flybase description The gene Cyclin-dependent kinase 8 is referred to in FlyBase by the symbol Dmel\Cdk8 (CG10572, FBgn0015618).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -18.1928 -14.16 -14.069935 -17.3806 -16.230512 -16.3069 -25.55647 -18.223088
    Affimetrix absolute value 4.259 3.797 4.388 4.294 4.739 4.561 3.915 4.06
    Affymetric present call in "x" number of chips 3 1 1 1 1 1 1 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: cyclin-dependent protein kinase activity.
There is experimental evidence that it is involved in the biological process: bristle development; axon guidance; sex comb development; G1/S transition of mitotic cell cycle; mitotic cell cycle G2/M transition DNA damage checkpoint; leg segmentation; cell cycle.
8 alleles are reported.
The phenotype of these alleles is annotated with: mesothoracic tergum.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages.