Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Rab7
Flybase description The gene Rab-protein 7 is referred to in FlyBase by the symbol Dmel\Rab7 (CG5915, FBgn0015795).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 8.6781 9.7063 4.351777 7.4319 2.682154 5.1517 6.66341 4.290326
    Affimetrix absolute value 11.51 10.882 10.266 11.265 10.126 10.924 11.27 10.236
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: GTPase activity.
There is experimental evidence that it is involved in the biological process: endosome to lysosome transport; dsRNA transport; endocytosis; autophagic cell death; negative regulation of growth of symbiont in host; salivary gland cell autophagic cell death; endosome transport.
18 alleles are reported.
The phenotypes of these alleles are annotated with: glial cell; eye disc; late endosome; wing.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Rab type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed during late larval stages, during early pupal stages.