Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name dpa
Flybase description The gene disc proliferation abnormal is referred to in FlyBase by the symbol Dmel\dpa (CG1616, FBgn0015929).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -33.7471 -16.2303 -22.49079 -22.0767 -27.613159 -18.3804 -40.88812 -26.314604
    Affimetrix absolute value 3.343 3.6 3.698 3.925 4.004 4.39 3.204 3.576
    Affymetric present call in "x" number of chips 0 0 0 0 1 2 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: 3'-5' DNA helicase activity.
There is experimental evidence that it is involved in the biological process: mitotic spindle organization; DNA replication.
13 alleles are reported.
The phenotypes of these alleles are annotated with: chromosome, centromeric region; trichogen cell; central nervous system; mitotic cell cycle; spindle; mesothoracic tergum; imaginal disc; mitotic metaphase.
It has one annotated transcript and one annotated polypeptide.
Protein features are: ATPase, AAA+ type, core; Mini-chromosome maintenance complex protein 4; Mini-chromosome maintenance, DNA-dependent ATPase; Mini-chromosome maintenance, conserved site; Nucleic acid-binding, OB-fold; Nucleic acid-binding, OB-fold-like; Rubredoxin-type Fe(Cys)4 protein.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages.