Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Cdk4
Flybase description The gene Cyclin-dependent kinase 4 is referred to in FlyBase by the symbol Dmel\Cdk4 (CG5072, FBgn0016131).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -6.7629 -3.2414 -4.025569 -1.7476 -7.299898 -3.535 -8.18204 -5.037059
    Affimetrix absolute value 5.674 5.946 6.19 7.589 5.931 6.762 5.522 5.995
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: cyclin binding.
There is experimental evidence that it is involved in the biological process: blastoderm segmentation; cell proliferation; cell growth; JAK-STAT cascade; cell cycle; mitochondrion organization; open tracheal system development.
35 alleles are reported.
The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; adult; abdominal 4 ventral denticle belt; cell cycle; mesothoracic tergum; wing; embryo; denticle belt.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 06-12 hour embryonic stages.