Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name lok
Flybase description The gene loki is referred to in FlyBase by the symbol Dmel\lok (CG10895, FBgn0019686).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -7.9704 -8.2549 -10.31075 -7.6992 -11.889162 -7.7209 -9.4122 -14.256844
    Affimetrix absolute value 5.42 4.592 4.828 5.452 5.192 5.628 5.34 4.497
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein kinase activity; protein serine/threonine kinase activity.
There is experimental evidence that it is involved in the biological process: apoptosis; activation of caspase activity; germ cell programmed cell death; response to DNA damage stimulus; germ cell development; DNA damage response, signal transduction resulting in induction of apoptosis; DNA damage checkpoint.
14 alleles are reported.
The phenotype of these alleles is annotated with: egg chamber.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Forkhead-associated (FHA) domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SMAD/FHA domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages, in adult female stages.