|Home||Overview of gut regions||Anatomy||Histology||Transgene expression mapping||Gene expression|
|Search expression data by gene:|
|Flybase description||The gene loki is referred to in FlyBase by the symbol Dmel\lok (CG10895, FBgn0019686).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein kinase activity; protein serine/threonine kinase activity.
There is experimental evidence that it is involved in the biological process: apoptosis; activation of caspase activity; germ cell programmed cell death; response to DNA damage stimulus; germ cell development; DNA damage response, signal transduction resulting in induction of apoptosis; DNA damage checkpoint.
14 alleles are reported.
The phenotype of these alleles is annotated with: egg chamber.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Forkhead-associated (FHA) domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SMAD/FHA domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages, in adult female stages.