Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Ice
Flybase description The gene Ice is referred to in FlyBase by the symbol Dmel\Ice (CG7788, FBgn0019972).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -0.386 1.26 1.494868 0.3878 1.173587 1.7572 -3.37883 1.335088
    Affimetrix absolute value 8.337 7.951 8.751 8.46 8.98 9.373 6.817 8.647
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: cysteine-type endopeptidase activity.
There is experimental evidence that it is involved in the biological process: salivary gland histolysis; spermatid differentiation; programmed cell death; sterol regulatory element binding protein cleavage; neuron remodeling; positive regulation of compound eye retinal cell programmed cell death; response to X-ray; developmental programmed cell death.
29 alleles are reported.
The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; organ system subdivision; adult; multicellular structure; external compound sense organ; adult segment; region of integument; cell part; imaginal precursor; multi-tissue structure; anatomical structure; cell projection.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, ICE, catalytic subunit p20, active site; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages.