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|Flybase description||The gene Ice is referred to in FlyBase by the symbol Dmel\Ice (CG7788, FBgn0019972).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: cysteine-type endopeptidase activity.
There is experimental evidence that it is involved in the biological process: salivary gland histolysis; spermatid differentiation; programmed cell death; sterol regulatory element binding protein cleavage; neuron remodeling; positive regulation of compound eye retinal cell programmed cell death; response to X-ray; developmental programmed cell death.
29 alleles are reported.
The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; organ system subdivision; adult; multicellular structure; external compound sense organ; adult segment; region of integument; cell part; imaginal precursor; multi-tissue structure; anatomical structure; cell projection.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, ICE, catalytic subunit p20, active site; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages.