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|Flybase description||The gene ATP citrate lyase is referred to in FlyBase by the symbol Dmel\ATPCL (CG8322, FBgn0020236).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ATP citrate synthase activity.
Based on sequence similarity, it is predicted to be involved in the biological process: citrate metabolic process; acetyl-CoA biosynthetic process.
14 alleles are reported.
The phenotype of these alleles is annotated with: mesothoracic tergum.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: ATP-citrate lyase/succinyl-CoA ligase; ATP-citrate lyase/succinyl-CoA ligase, active site; ATP-citrate synthase; ATP-grasp fold, subdomain 2; ATP-grasp fold, succinyl-CoA synthetase-type; Citrate synthase-like; Citrate synthase-like, core; Citrate synthase-like, large alpha subdomain; Citrate synthase-like, small alpha subdomain; CoA-binding; NAD(P)-binding domain; Succinyl-CoA ligase, alpha subunit; Succinyl-CoA synthetase, beta subunit, conserved site; Succinyl-CoA synthetase-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression.
Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.