Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name sfl
Flybase description The gene sulfateless is referred to in FlyBase by the symbol Dmel\sfl (CG8339, FBgn0020251).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -16.5753 -3.4343 -7.317994 -13.4679 -18.863513 -16.5166 -20.71959 -13.642219
    Affimetrix absolute value 4.364 5.844 5.332 4.679 4.548 4.523 4.194 4.495
    Affymetric present call in "x" number of chips 1 3 3 3 3 3 2 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: [heparan sulfate]-glucosamine N-sulfotransferase activity.
There is experimental evidence that it is involved in the biological process: fibroblast growth factor receptor signaling pathway; glycosaminoglycan biosynthetic process; mesoderm migration involved in gastrulation; synaptic vesicle endocytosis; intracellular distribution of mitochondria; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; sulfur compound metabolic process; Wnt receptor signaling pathway; segment polarity determination; epithelial cell migration, open tracheal system.
17 alleles are reported.
The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; multicellular structure; portion of tissue; tracheal system; anatomical structure; acellular anatomical structure; organ system subdivision; non-connected developing system; synapse; embryonic/larval integumentary system; adult segment.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Heparan sulphate-N-deacetylase; Sulfotransferase domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-18 hour embryonic stages.