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|Flybase description||The gene locomotion defects is referred to in FlyBase by the symbol Dmel\loco (CG5248, FBgn0020278).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: G-protein alpha-subunit binding; GTPase activator activity.
There is experimental evidence that it is involved in the biological process: regulation of G-protein coupled receptor protein signaling pathway; glial cell differentiation; asymmetric neuroblast division; asymmetric protein localization; dorsal/ventral axis specification, ovarian follicular epithelium; establishment of glial blood-brain barrier; cytoplasmic transport, nurse cell to oocyte; cortical actin cytoskeleton organization; septate junction assembly; ventral cord development.
43 alleles are reported.
The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: multicellular structure; organ system; anatomical structure; acellular anatomical structure; non-connected developing system; portion of tissue; eo support cell; male accessory gland; cytoplasmic part; organ system subdivision; embryonic foregut.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: GoLoco motif; PDZ/DHR/GLGF; Phosphotyrosine interaction domain; Pleckstrin homology-type; Raf-like Ras-binding; Regulator of G protein signalling; Regulator of G protein signalling superfamily; Regulator of G-protein signaling, domain 1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages.