Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name loco
Flybase description The gene locomotion defects is referred to in FlyBase by the symbol Dmel\loco (CG5248, FBgn0020278).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -0.517 1.2322 -0.460312 -1.6737 -1.915485 -1.7086 -3.27515 -1.459998
    Affimetrix absolute value 8.192 7.901 8.02 7.692 7.837 7.851 6.876 7.733
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: G-protein alpha-subunit binding; GTPase activator activity.
There is experimental evidence that it is involved in the biological process: regulation of G-protein coupled receptor protein signaling pathway; glial cell differentiation; asymmetric neuroblast division; asymmetric protein localization; dorsal/ventral axis specification, ovarian follicular epithelium; establishment of glial blood-brain barrier; cytoplasmic transport, nurse cell to oocyte; cortical actin cytoskeleton organization; septate junction assembly; ventral cord development.
43 alleles are reported.
The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: multicellular structure; organ system; anatomical structure; acellular anatomical structure; non-connected developing system; portion of tissue; eo support cell; male accessory gland; cytoplasmic part; organ system subdivision; embryonic foregut.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: GoLoco motif; PDZ/DHR/GLGF; Phosphotyrosine interaction domain; Pleckstrin homology-type; Raf-like Ras-binding; Regulator of G protein signalling; Regulator of G protein signalling superfamily; Regulator of G-protein signaling, domain 1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages.