Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name dom
Flybase description The gene domino is referred to in FlyBase by the symbol Dmel\dom (CG9696, FBgn0020306).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -6.5482 -2.1207 -3.834949 -4.0416 -7.037978 -4.3844 -5.20391 -6.187144
    Affimetrix absolute value 5.738 6.535 6.269 6.394 5.971 6.436 6.22 5.705
    Affymetric present call in "x" number of chips 2 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: gene silencing; chromatin organization; negative regulation of gene expression; instar larval or pupal development; positive regulation of Notch signaling pathway; oogenesis; wing disc pattern formation; regulation of alternative nuclear mRNA splicing, via spliceosome; neurogenesis; dendrite guidance.
31 alleles are reported.
The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; multicellular structure; imaginal precursor; organ system subdivision; anatomical structure; embryonic/larval hemocoel; adult segment; embryonic/larval imaginal precursor; eo support cell; circulatory system; late extended germ band embryo.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: DEAD-like helicase; HAS subgroup; HSA; Helicase, C-terminal; Helicase/SANT-associated, DNA binding; MYB-like; SNF2-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 and 18-24 hour embryonic stages, in adult female stages.