Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name crol
Flybase description The gene crooked legs is referred to in FlyBase by the symbol Dmel\crol (CG14938, FBgn0020309).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.2072 -2.326 -5.408581 -5.0064 -9.625573 -5.2193 -2.41209 -7.826022
    Affimetrix absolute value 6.03 6.404 5.809 6.075 5.582 6.187 7.359 5.313
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding.
There is experimental evidence that it is involved in the biological process: lateral inhibition; cell adhesion; negative regulation of Wnt receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; regulation of chromatin silencing; imaginal disc-derived wing morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of mitotic cell cycle.
50 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: adult segment; organ system subdivision; thoracic segment; imaginal precursor; organ system; portion of tissue; multicellular structure; appendage segment; stage P14 pharate adult; epithelial furrow.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 06-18 hour embryonic stages, during early pupal stages.