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|Flybase description||The gene crooked legs is referred to in FlyBase by the symbol Dmel\crol (CG14938, FBgn0020309).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding.
There is experimental evidence that it is involved in the biological process: lateral inhibition; cell adhesion; negative regulation of Wnt receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; regulation of chromatin silencing; imaginal disc-derived wing morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of mitotic cell cycle.
50 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: adult segment; organ system subdivision; thoracic segment; imaginal precursor; organ system; portion of tissue; multicellular structure; appendage segment; stage P14 pharate adult; epithelial furrow.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 06-18 hour embryonic stages, during early pupal stages.