Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Dredd
Flybase description The gene Death related ced-3/Nedd2-like protein is referred to in FlyBase by the symbol Dmel\Dredd (CG7486, FBgn0020381).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.8718 -1.2463 -1.808421 -1.9618 -2.466313 -2.038 -1.95496 -2.39991
    Affimetrix absolute value 7.524 7.303 7.326 7.423 7.474 7.536 7.596 7.031
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; apoptotic protease activator activity; endopeptidase activity.
There is experimental evidence that it is involved in the biological process: immune response; apoptosis; peripheral nervous system neuron development; sperm individualization; defense response to Gram-negative bacterium; peptidoglycan recognition protein signaling pathway; defense response; protein maturation by peptide bond cleavage.
31 alleles are reported.
The phenotypes of these alleles are annotated with: spermatid; mesothoracic tergum.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed during late larval stages, at stages throughout the pupal period.