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|Flybase description||The gene pugilist is referred to in FlyBase by the symbol Dmel\pug (CG4067, FBgn0020385).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity; formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity.
An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; folic acid-containing compound biosynthetic process.
18 alleles are reported.
The phenotypes of these alleles are annotated with: eye; pigment cell.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Formate-tetrahydrofolate ligase, FTHFS; Formate-tetrahydrofolate ligase, FTHFS, conserved site; NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed during early larval stages, during early pupal stages.