Flygut: an atlas of the Drosophila adult midgut

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Gene name pug
Flybase description The gene pugilist is referred to in FlyBase by the symbol Dmel\pug (CG4067, FBgn0020385).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.5933 -2.0052 0.558742 -1.8253 -1.089437 -2.5098 -1.29386 -0.536598
    Affimetrix absolute value 6.567 6.641 8.448 7.527 8.638 7.241 7.783 8.008
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity; formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity.
An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; folic acid-containing compound biosynthetic process.
18 alleles are reported.
The phenotypes of these alleles are annotated with: eye; pigment cell.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Formate-tetrahydrofolate ligase, FTHFS; Formate-tetrahydrofolate ligase, FTHFS, conserved site; NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed during early larval stages, during early pupal stages.