Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name scu
Flybase description The gene scully is referred to in FlyBase by the symbol Dmel\scu (CG7113, FBgn0021765).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -38.2366 -23.6791 -34.197246 -31.0751 -48.978523 -42.0015 -19.95768 -33.873965
    Affimetrix absolute value 3.214 3.072 3.117 3.439 3.163 3.179 4.254 3.174
    Affymetric present call in "x" number of chips 0 0 0 3 0 3 3 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: steroid dehydrogenase activity; 7-beta-hydroxysteroid dehydrogenase (NADP+) activity; acetoacetyl-CoA reductase activity; testosterone dehydrogenase (NAD+) activity; testosterone 17-beta-dehydrogenase (NAD+) activity; estradiol 17-beta-dehydrogenase activity.
There is experimental evidence that it is involved in the biological process: acyl-CoA metabolic process; fatty acid metabolic process; estrogen metabolic process; androgen metabolic process; steroid metabolic process; ecdysone metabolic process.
14 alleles are reported.
The phenotypes of these alleles are annotated with: testis; spermatocyte.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Glucose/ribitol dehydrogenase; NAD(P)-binding domain; Short-chain dehydrogenase/reductase SDR; Short-chain dehydrogenase/reductase, conserved site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.