Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Vps25
Flybase description The gene Vacuolar protein sorting 25 is referred to in FlyBase by the symbol Dmel\Vps25 (CG14750, FBgn0022027).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.5024 -1.4012 -1.431207 -0.4722 -1.614087 -1.4723 -2.28081 -1.533859
    Affimetrix absolute value 7.821 7.14 7.671 8.207 8.068 8.011 7.363 7.632
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Its molecular function is unknown.
There is experimental evidence that it is involved in the biological process: regulation of apoptosis; regulation of multivesicular body size involved in endosome transport; cell proliferation; negative regulation of epithelial cell proliferation; regulation of Notch signaling pathway; endosome transport via multivesicular body sorting pathway; epithelial structure maintenance; maintenance of epithelial cell apical/basal polarity; cell differentiation; endosome transport.
17 alleles are reported.
The phenotype of these alleles is annotated with: embryonic/larval digestive system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: ESCRT-II complex, vps25 subunit; ESCRT-II complex, vps25 subunit, C-terminal winged helix; ESCRT-II complex, vps25 subunit, N-terminal winged helix.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression.
Peak expression observed within 00-12 hour embryonic stages.