Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Sin3A
Flybase description The gene Sin3A is referred to in FlyBase by the symbol Dmel\Sin3A (CG8815, FBgn0022764).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -25.3584 -7.6089 -14.927086 -12.2541 -36.262166 -13.7499 -11.01186 -22.873671
    Affimetrix absolute value 3.816 4.721 4.315 4.808 3.657 4.787 5.107 3.961
    Affymetric present call in "x" number of chips 0 3 0 2 0 3 3 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; neuron development; regulation of mitotic cell cycle; muscle organ development; negative regulation of transcription, DNA-dependent.
60 alleles are reported.
The phenotypes of these alleles are annotated with: trichogen cell; heart primordium; mesothoracic tergum; mitochondrion; crystal cell.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: Histone deacetylase interacting; Paired amphipathic helix.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, in adult female stages.