Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Hel89B
Flybase description The gene Helicase 89B is referred to in FlyBase by the symbol Dmel\Hel89B (CG4261, FBgn0022787).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.0323 -2.4579 -4.28041 -3.849 -7.655833 -5.1249 -3.91981 -6.879495
    Affimetrix absolute value 6.4 6.328 6.088 6.465 5.881 6.205 6.605 5.554
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ATP-dependent DNA helicase activity.
There is experimental evidence that it is involved in the biological process: innate immune response; Toll signaling pathway; defense response to bacterium; positive regulation of antibacterial peptide biosynthetic process; antimicrobial humoral response.
17 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Armadillo-like helical; Armadillo-type fold; DEAD-like helicase; Domain of unknown function DUF3535; Helicase, C-terminal; SNF2-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period.