Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Clk
Flybase description The gene Clock is referred to in FlyBase by the symbol Dmel\Clk (CG7391, FBgn0023076).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.8216 -2.0405 -5.980119 -3.8772 -15.087318 -5.4563 -2.19178 -8.623471
    Affimetrix absolute value 6.481 6.603 5.835 6.456 5.009 6.128 7.432 5.43
    Affymetric present call in "x" number of chips 3 3 3 3 2 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; protein heterodimerization activity; DNA binding.
There is experimental evidence that it is involved in the biological process: regulation of circadian sleep/wake cycle, sleep; circadian rhythm; locomotor rhythm; positive regulation of transcription, DNA-dependent; circadian regulation of gene expression.
27 alleles are reported.
The phenotype of these alleles is annotated with: larval LN period neuron.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Helix-loop-helix DNA-binding; Helix-loop-helix DNA-binding domain; Nuclear translocator; PAC motif; PAS; PAS fold-3.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected.
Peak expression observed in adult male stages.