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|Flybase description||The gene Ubiquitin activating enzyme 1 is referred to in FlyBase by the symbol Dmel\Uba1 (CG1782, FBgn0023143).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ubiquitin activating enzyme activity.
There is experimental evidence that it is involved in the biological process: regulation of Ras protein signal transduction; cell proliferation; neuron remodeling; mushroom body development; lipid storage; protein ubiquitination.
42 alleles are reported.
The phenotypes of these alleles are annotated with: leg; proboscis; macrochaeta; humeral disc; intersegmental nerve; eye disc posterior to the morphogenetic furrow.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Molybdenum cofactor biosynthesis, MoeB; NAD(P)-binding domain; UBA/THIF-type NAD/FAD binding fold; Ubiquitin-activating enzyme; Ubiquitin-activating enzyme e1, C-terminal; Ubiquitin-activating enzyme repeat; Ubiquitin-activating enzyme, E1; Ubiquitin-activating enzyme, E1, active site; Ubiquitin-like 1 activating enzyme, catalytic cysteine domain; Ubiquitin/SUMO-activating enzyme E1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.