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|Flybase description||The gene RhoGEF2 is referred to in FlyBase by the symbol Dmel\RhoGEF2 (CG9635, FBgn0023172).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: diacylglycerol binding; Rho guanyl-nucleotide exchange factor activity.
There is experimental evidence for 15 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; morphogenesis of embryonic epithelium; anatomical structure formation involved in morphogenesis; regulation of developmental process; multicellular organismal development; actin filament-based process; gastrulation; regulation of cell morphogenesis; pole cell development; morphogenesis of an epithelial fold; organelle organization; embryonic development via the syncytial blastoderm; open tracheal system development.
42 alleles are reported.
The phenotypes of these alleles are annotated with: presumptive embryonic salivary gland; wing disc; epithelial cell; posterior spiracle primordium; wing; mesoderm anlage; ventral midline.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Dbl homology (DH) domain; PDZ/DHR/GLGF; Pleckstrin homology domain; Pleckstrin homology-type; Protein kinase C-like, phorbol ester/diacylglycerol binding; Regulator of G protein signalling superfamily; Regulator of G protein signalling-like fold; Rho GTP exchange factor.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.